| SES # | TOPICS | LECTURE NOTES |
|---|---|---|
| 1 | Introduction to the problem | (PDF) |
| 2 | Side-chain review Sulfur redox chemistry | |
| 3 | The Anfinsen experiments | (PDF) |
| 4 | Globular protein structure Protein interiors | (PDF) |
| 5 | Using the Protein database (PDB) | (PDF - 2.5 MB) (Courtesy of Prof. David Gossard) |
| 6 | Helix-helix packing in globular proteins | (PDF) |
| 7 | Beta-sheets Beta-sheet packing | (PDF) |
| 8 | Experimental techniques: circular dichroism | |
| 9 | Thermal denaturation Coiled coils Refolding of tropomyosin | (PDF 1) (Courtesy of Prof. David Gossard) (PDF 2) |
| 10 | Fluorescence spectroscopy | |
| 11 | S-peptide helical folding | (PDF) |
| 12 | Detecting partially folded intermediates | (PDF) |
| 13 | Prolyl isomerization | |
| 14 | Cytochrome c refolding pathway | (PDF) |
| 15 | 2-D NMR techniques | |
| 16 | Collagen structure and folding in vivo | (PDF - 1.8 MB) (Courtesy of Prof. David Gossard) |
| 17 | Procollagen folding in vitro | |
| 18 | Protein calorimetry: BPTI | |
| 19 | Protein misfolding and aggregation | (PDF) |
| 20 | Ribosome channel Nascent chains Trigger factor | (PDF) |
| 21 | Scaffolding proteins in viral shell assembly | |
| 22 | Amyloid fiber formation in neuro degenerative disease | |
| 24 | Chaperonin assisted folding | (PDF) |
| 25 | Eukariotic chaperonins | |
| 26 | Paper topic discussion and choices | |
| 27 | Membrane protein (rhodopsin) folding and assembly | |
| 28 | Prion diseases | |
| 29 | Etiology of some human protein deposition diseases |