| ASSIGNMENTS | SOLUTIONS | READINGS | ASSIGNMENTS DUE |
|---|---|---|---|
Assignment 1 (PDF) | Branden and Tooze. Chapter 1 and chapter 2, pp. 13-17. Pauling, Linus, Robert B. Corey, and H. R. Branson. "The Structure of Proteins: Two Hydrogen Bonded Helical Configurations of the Polypeptide Chain." Proc Nat Acad Sci 37 (1951): 205-210. Perutz, Max F. "I Wish I'd Made you Angry Earlier." In I Wish I'd Made you Angrier Earlier: Essays on Science, Scientists & Humanity. Cold Springs Harbor Lab Press, 1998, pp. 173-174. Graduate students only Pauling, Linus, Robert B. Corey, and H. R. Branson. "The Structure of Proteins: Two Hydrogen Bonded Helical Configurations of the Polypeptide Chain." Proc Nat Acad Sci, USA 37 (1951): 205-210. | Ses #4 | |
Assignment 2 (PDF) | Anfinsen, C. B., E. Haber, M. Sela, and F. H. White, Jr. "The Kinetics of Formation of Native Ribonuclease During Oxidation of the Reduced Polypeptide Chain." PNAS 47 (1961): 1309-1314. Branden and Tooze. Chapters 2 and 3. Gusker, J. P. "Crystallizing the Life of Dorothy Hodgkin." Chem Eng News 78 (2000): 28-30. Not required Pauling, Linus. "Modern Structural Chemistry." Nobel Prize Lecture. Stockholm, Sweden, 1954. ———. "Science and Peace." Nobel Prize Lecture. Stocholm, Sweden, 1962. | ||
Assignment 3 (PDF) | Branden and Tooze. Chapter 4 and chapter 5, pp. 67-80. | Ses #8 | |
Assignment 4 (PDF) | Branden and Tooze. Chapter 15. | Ses #10 | |
Assignment 5 (PDF) | Assignment 5 key (PDF) | Marquesee, Susan, and Robert L. Baldwin. "A-Helix Formation by Short Peptides in Water." Protein Folding: Deciphering the Second Half of the Genetic Code. Edited by Lila M. Gierasch, and Jonathan King. Washington, DC: AAAS, 1990. Richardson, Jane S., and David C. Richardson. "Amino Acid Preferences for specific Locations at the Ends of a Helices." Science 240 (1988): 1648-1652. Presta, L. G., and G. D. Rose. "Helix Signals in Proteins." Science 240 (1988): 1632-1640. Graduate students only Harper, E. T. and G. D. Rose. "Helix Stop Signals in Proteins and Peptides: The Capping Box." Biochemistry 32 (1993): 7605-7609. | Ses #13 |
Assignment 6 (PDF) | Assignment 6 key (PDF) | Branden and Tooze. pp. 286-297. O'Shea, E., R. Rutkowski, and P. S. Kim. "Evidence that the Leucine Zipper is a Coiled Coil." Science 243 (1989): 538-542. | Ses #14 |
Assignment 7 (PDF) | Branden and Tooze. Chapter 14. Kuivaniemi, H., G. Tromp, and D. J. Prockop. "Mutations in Collagen Genes: Causes of Rare and Some Common Diseases in Humans." FASEB Journal 5 (1991): 2025-2060. | Ses #16 | |
Graded problem set (PDF) | Problem set key (PDF) | Ses #20 |
Table of Contents
Assignments
Assignments
 When you click the Amazon logo to the left of any citation and purchase the book (or other media) from Amazon.com, MIT OpenCourseWare will receive up to 10% of this purchase and any other purchases you make during that visit. This will not increase the cost of your purchase. Links provided are to the US Amazon site, but you can also support OCW through Amazon sites in other regions. Learn more. |
Assigned readings in Branden and Tooze are from the course textbook:
Branden, Carl, and John Tooze. Introduction to Protein Structure. 2nd ed. New York, NY: Garland Science, 1999. ISBN: 9780815323051.
Solutions are available for a selected assignments.