Table of Contents
Study Materials
Readings
 Help support MIT OpenCourseWare by shopping at Amazon.com! MIT OpenCourseWare offers direct links to Amazon.com to purchase the books cited in this course. Click on the Amazon logo to the left of any citation and purchase the book from Amazon.com, and MIT OpenCourseWare will receive up to 10% of all purchases you make. Your support will enable MIT to continue offering open access to MIT courses. |
The course textbook by Prof. Grodzinsky (Fields, Forces and Flows in Biological Systems) was provided to students as an unpublished manuscript.
References to "Deen" below are from the text: Deen, W. M. Analysis of Transport Phenomena. New York, NY: Oxford University Press, 1998. ISBN: 9780195084948.
| ses # | TOPICS | readings | |
|---|---|---|---|
| L1 | Introduction/Summary Examples | Grodzinsky. Chapter 2, "Membrane Transport Phenomena." Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix. | |
| I. Chemical Subsystem | |||
| L2 | Continuity of Chemical Species, Flux, Reaction Rates, Boundary Conditions | Grodzinsky. Chapter 2, "Membrane Transport Phenomena." Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix. | |
| L3 | Diffusion Begin Reaction Damkohler # Scaling and Approximations | Grodzinsky. Chapter 2, "Membrane Transport Phenomena." Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix. | |
| L4 | Example Problems: Separation of Variables Method | Grodzinsky. Chapter 2, "Membrane Transport Phenomena." Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix. | |
| L5 | Example Problems: Separation of Variables Method (cont.) Case Study: IGF Problem from Lecture L1 using Matrix Continuum Distribution of IGF Binding Proteins Numerical Considerations (if time) | Grodzinsky. Chapter 2, "Membrane Transport Phenomena." Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix. | |
| III. Cellular Applications | |||
| L14 | Experimental Methods | Paper for discussion: Graff, C., and D. Wittrup. "Theoretical Analysis of Antibody Targeting of Tumor Spheroids: Importance of Dosage for Penetration, and Affinity for Retention." Cancer Res 2003. | |
| L15 | Ligand Binding to Cell Receptors | Paper for discussion: Haugh, et. al. "Spatial Sensing in Fibroblasts Mediated by 3' Phosphoinositides." J Cell Biol. 151, no. 6 (2000): 1269. ———. "Online Supplemental Material." J. Cell Biol. 151, no. 6 (2000). | |