| SES # | TOPICS | READINGS |
|---|---|---|
| 1 | Overview of the class, introduction to glia and use of pubmed | Barres, B. A. "What is a Glial Cell? " Glia 43, no. 1 (July 2003): 4-5. Somjen, G. G. "Nervenkitt: Notes on the History of the Concept of Neuroglia." Glia 1, no. 1 (1988): 2-9. |
| 2 | Myelination in the peripheral nervous system (PNS): Schwann cells | Eshed, Y., K. Feinberg, S. Poliak, H. Sabanay, O. Sarig-Nadir, I. Spiegel, J. R. Jr. Bermingham, and E. Peles. "Gliomedin Mediates Schwann Cell-axon Interaction and the Molecular Assembly of the Nodes of Ranvier." Neuron 47, no. 2 (July 21, 2005): 215-29. Oh, S., Y. Ri, M. V. Bennett, E. B. Trexler, V. K. Verselis, T. A. Bargiello. "Changes in Permeability Caused by Connexin 32 Mutations Underlie X-linked Charcot-Marie-Tooth Disease." Neuron 19, no. 4 (October 1997): 927-38. |
| 3 | Myelination in the central nervous system (CNS): Oligodendrocytes | Kaplan, M. R., M. H. Cho, E. M. Ullian, L. L. Isom, S. R. Levinson, and B. A. Barres. "Differential Control of Clustering of the Sodium Channels Na(v)1.2 and Na(v)1.6 at Developing CNS Nodes of Ranvier." Neuron 30, no. 1 (April 2001): 105-19. Craner, M. J., J. Newcombe, J. A. Black, C. Hartle, M. L. Cuzner, and S. G. Waxman. "Molecular Changes in Neurons in Multiple Sclerosis: Altered Axonal Expression of Nav1.2 and Nav1.6 Sodium Channels and Na+/Ca2+ Exchanger." Proc Natl Acad Sci U.S.A. 101, no. 21 (May 25, 2004): 8168-73. |
| 4 | The Nogo hypothesis | Zheng, B., C. Ho, S. Li, H. Keirstead, O. Steward, and M. Tessier-Lavigne. "Lack of Enhanced Spinal Regeneration in Nogo-deficient Mice." Neuron 38, no. 2 (April 24, 2003): 213-24. Karnezis, T., W. Mandemakers, J. L. McQualter, B. Zheng, P. P. Ho, K. A. Jordan, B. M. Murray, B. Barres, M. Tessier-Lavigne, and C. C. Bernard. "The Neurite Outgrowth Inhibitor Nogo A is Involved in Autoimmune-mediated Demyelination." Nat Neurosci 7, no. 7 (July 2004): 736-44. |
| 5 | Neuregulin-1 and schizophrenia | Michailov, G. V., M. W. Sereda, B. G. Brinkman, T. M. Fischer, B. Haug, C. Birchmeier, L. Role, C. Lai, M. H. Schwab, and K. A. Nave. "Axonal Neuregulin-1 Regulates Myelin Sheath Thickness." Science 30, no. 5671 (April 30, 2004): 700-3. Hahn, C. G., H. Y. Wang, D. S. Cho, K. Talbot, R. E. Gur, W. H. Berrettini, K. Bakshi, J. Kamins, K. E. Borgmann-Winter, S. J. Siegel, R. J. Gallop, and S. E. Arnold. "Altered Neuregulin 1-erbB4 Signaling Contributes to NMDA Receptor Hypofunction in Schizophrenia." Nat Med 12, no. 7 (July 2006): 824-8. |
| 6 | Field trip | Roy, Kristine, Dr. "Loss of erbB Signaling in Oligodendrocytes Alters Myelin and Dopaminergic Function, a Potential Mechanism for Neuropsychiatric Disorders." Proc Natl Acad Sci U S A 104, no. 19 (May 8, 2007): 8131-6. |
| 7 | CNS Astrocytes, part I: Interactions with oligodendrocytes | Ishibashi, T., K. A. Dakin, B. Stevens, P. R. Lee, S. V. Kozlov, C. L. Stewart, and R. D. Fields. "Astrocytes Promote Myelination in Response to Electrical Impulses." Neuron 49, no. 6 (March 16, 2006): 823-32. Antony, J. M., G. van Marle, W. Opii, D. A. Butterfield, F. Mallet, V. W. Yong, J. L. Wallace, R. M. Deacon, K. Warren, and C. Power. "Human Endogenous Retrovirus Glycoprotein-mediated Induction of Redox Reactants Causes Oligodendrocyte Death and Demyelination ." Nat Neurosci 7, no. 10 (October 2004): 1088-95. |
| 8 | CNS Astrocytes, part II: Neuromodulation and Alzheimer's disease | Beattie, E. C., D. Stellwagen, W. Morishita, J. C. Bresnahan, B. K. Ha, M. Von Zastrow, M. S. Beattie, and R. C. Malenka. "Control of Synaptic Strength by Glial TNFalpha." Science 295, no. 5563 (March 22, 2002): 2282-5. Rossi, D., L. Brambilla, C. F. Valori, A. Crugnola, G. Giaccone, R. Capobianco, M. Mangieri, A. E. Kingston, A. Bloc, P. Bezzi, and A. Volterra. "Defective Tumor Necrosis Factor-alpha-dependent Control of Astrocyte Glutamate Release in a Transgenic Mouse Model of Alzheimer Disease." J Biol Chem 280, no. 51 (December 23, 2005): 42088-96. |
| 9 | CNS Astrocytes, part III: Synaptogenesis and epilepsy | Ullian, E. M., S. K. Sapperstein, K. S. Christopherson, and B. A. Barres. "Control of Synapse Number by Glia." Science 291, no. 5504 (January 26, 2001): 657-61. Tian, G. F., H. Azmi, T. Takano, Q. Xu, W. Peng, J. Lin, N. Oberheim, N. Lou, X. Wang, H. R. Zielke, J. Kang, and M. Nedergaard. "An Astrocytic Basis of Epilepsy." Nat Med 11, no. 9 (September 2005): 973-81. |
| 10 | CNS Astrocytes, part IV: The role of glial cells in adult neurogenesis | Doetsch, F., I. Caille, D. A. Lim, J. M. Garcia-Verdugo, and A. Alvarez-Buylla. "Subventricular Zone Astrocytes are Neural Stem Cells in the Adult Mammalian Brain." Cell 97, no. 6 (June 11, 1999): 703-16. Song, H., C. F. Stevens, and F. H. Gage. "Astroglia Induce Neurogenesis from Adult Neural Stem Cells." Nature 417, no. 6884 (May 2, 2002): 39-44. |
| 11 | CNS Astrocytes, part V: Gliomas | Takano, T., J. H. Lin, G. Arcuino, Q. Gao, J. Yang, and M. Nedergaard. "Glutamate Release Promotes Growth of Malignant Gliomas." Nat Med 7, no. 9 (September 2001): 1010-5. Piccirillo, S. G., B. A. Reynolds, N. Zanetti, G. Lamorte, E. Binda, G. Broggi, H. Brem, A. Olivi, F. Dimeco, and A. L. Vescovi. "Bone Morphogenetic Proteins Inhibit the Tumorigenic Potential of Human Brain Tumour-initiating Cells." Nature 444, no. 7120 (December 7, 2006): 761-5. |
| 12 | Microglia of the CNS | Bezzi, P., M. Domercq, L. Brambilla, R. Galli, D. Schols, E. De Clercq, A. Vescovi, G. Bagetta, G. Kollias, J. Meldolesi, and A. Volterra. "CXCR4-activated Astrocyte Glutamate Release via TNFalpha: Amplification by Microglia Triggers Neurotoxicity." Nat Neurosci 4, no. 7 (July 2001): 702-10. Hains, B. C., and S. G. Waxman. "Activated Microglia Contribute to the Maintenance of Chronic Pain After Spinal Cord Injury." J Neurosci 26, no. 16 (April 19, 2006): 4308-17. |
| 13 | 2nd assignment: Oral presentations |