| SES # | TOPICS | READINGS |
|---|---|---|
| 1 | Overview and distribution of papers | |
| 2 | Phagocytosis | Alpuchearanda, C. M., Racoosin, E. L., Swanson, J. A., and Miller, S. I. "Salmonella Stimulate Macrophage Macropinocytosis and Persist within Spacious Phagosomes." Journal of Experimental Medicine 179 (1994): 601-608. Harrison, R. E., Brumell, J. H., Khandani, A., Bucci, C., Scott, C. C., Jiang, X. J., Finlay, B. B., and Grinstein, S. L. "Salmonella Impairs RILP Recruitment to Rab7 during Maturation of Invasion Vacuoles." Molecular Biology of the Cell 15 (2004): 3146-3154. |
| 3 | Toll-like receptors (TLRs) | Stack, J., Haga, I. R., Schroder, M., Bartlett, N. W., Maloney, G., Reading, P. C., Fitzgerald, K. A., Smith, G. L., and Bowie, A. G. "Vaccinia Virus Protein Toll-like-interleukin-1 A46R Targets Multiple Receptor Adaptors and Contributes to Virulence." Journal of Experimental Medicine 201 (2005): 1007-1018. Tomizawa, H., Takeda, K., and Akira, S. "Small Anti-viral Compounds Activate Immune Cells via the TLR7 MyD88-dependent Signaling Pathway." Nature Immunology 3 (2002): 196-200. |
| 4 | The proteasome and ubiquitin | Kattenhorn, L. M., Korbel, G. A., Kessler, B. M., Spooner, E., and Ploegh, H. L. "A Deubiquitinating Enzyme Encoded by HSV-1 belongs to a Family of Cysteine Proteases that is conserved across the Family Herpesviridae." Molecular Cell 19 (2005): 547-557. Zhou, H. L., Monack, D. M., Kayagaki, N., Wertz, I., Yin, J. P., Wolf, B., and Dixit, V. M. "Yersinia Virulence Factor YopJ acts as a Deubiquitinase to Inhibit NF-kappa B Activation." Journal of Experimental Medicine 202 (2005): 1327-1332. |
| 5 | Major histocompatibility (MHC) class I antigen presentation | Wiertz, E., Jones, T. R., Sun, L., Bogyo, M., Geuze, H. J., and Ploegh, H. L. "The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol." Cell 84 (1996): 769-779. Ye, Y. H., Shibata, Y., Yun, C., Ron, D., and Rapoport, T. A. "A Membrane Protein Complex Mediates Retro-translocation from the ER Lumen into the Cytosol." Nature 429 (2004): 841-847. |
| 6 | Major histocompatiblity (MHC) class II antigen presentation | Nef. Garcia, J. V., and Miller, A. D. "Serine Phosphorylation-independent Down-regulation of Cell-surface CD4." Nature 350 (1991): 508-511. Pancio, H. A., Vander Heyden, N., Kosuri, K., Cresswell, P., and Ratner, L. "Interaction of Human Immunodeficiency Virus Type 2 Vpx and Invariant Chain." Journal of Virology 74 (2000): 6168-6172. |
| 7 | Cytokines | Kledal, T. N., Rosenkilde, M. M., Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Power, C. A., Luttichau, H. R., Gerstoft, J., Clapham, P. R., ClarkLewis, I., Wells, T. N. C., and Schwartz, T. W. "A Broad-spectrum Chemokine Antagonist Encoded by Kaposi's Sarcoma-associated Herpesvirus." Science 277 (1997): 1656-1659. Deng, H. K., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., DiMarzio, P., Marmon, S., Sutton, R. E., Hill, C. M., Davis, C. B., Peiper, S. C., Schall, T. J., Littman, D. R., and Landau, N. R. "Identification of a Major Co-receptor for Primary Isolates of HIV-1." Nature 381 (1996): 661-666. |
| 8 | Programmed cell death | Everett, H., Barry, M., Lee, S. F., Sun, X. J., Graham, K., Stone, J., Bleackley, R. C., and McFadden, G. "M11L: A Novel Mitochondria-localized Protein of Myxoma Virus that Blocks Apoptosis of Infected Leukocytes." Journal of Experimental Medicine 191 (2000): 1487-1498. Henderson, S., Rowe, M., Gregory, C., Croomcarter, D., Wang, F., Longnecker, R., Kieff, E., and Rickinson, A. " Induction of Bcl-2 Expression by Epstein-Barr-Virus Latent Membrane Protein-1 Protects Infected B-cells from Programmed Cell-death." Cell 65 (1991): 1107-1115. |
| 9 | Molecular mimicry | Reyburn, H. T., Mandelboim, O., ValesGomez, M., Davis, D. M., Pazmany, L., and Strominger, J. L. "The Class I MHC Homologue of Human Cytomegalovirus inhibits attack by Natural Killer Cells." Nature 386 (1997): 514-517. Cosman, D., Fanger, N., Borges, L., Kubin, M., Chin, W., Peterson, L., and Hsu, M. L." A Novel Immunoglobulin Superfamily Receptor for Cellular and Viral MHC Class I Molecules." Immunity 7 (1997): 273-282. |
| 10 | Antimicrobial peptides: Innate immunity effectors | Bader, M. W., Sanowar, S., Daley, M. E., Schneider, A. R., Cho, U. S., Xu, W. Q., Klevit, R. E., Le Moual, H., and Miller, S. "Recognition of Antimicrobial Peptides by a Bacterial Sensor Kinase." Cell 122 (2005): 461-472. Legarda, D., Klein-Patel, M. E., Yim, S., Yuk, M. H., and Diamond, G. "Suppression of NF-kappa B-mediated Beta-defensin Gene Expression in the Mammalian Airway by the Bordetella Type III Secretion System." Cellular Microbiology 7 (2005): 489-497. |
| 11 | Oral presentation | |
| 12 | Oral presentation and general discussion |