Jobs:

Job No.

• Job Title:
• Postdoctoral Associate
• Employer:
• Baylor College of Medicine
• Location:
• Houston, TX
• Posting Date:
• 27-Nov-2025
• Apply
• Description:

• Title: Postdoctoral Associate

  Division: Pediatrics (80001016)

  Department:Pediatrics - Oncology AICT (90006806)

  Location: Houston (1100)

  Salary Range: $64,356

  Work Schedule: Monday – Friday, 8 a.m. – 5 p.m.

  Employment Duration: Full-time

  FLSA Status: Exempt

  Summary

  We seek a highly motivated postdoctoral fellow to lead a translational immunotherapy project focused on advancing next-generation CAR T-cell therapies for pediatric solid tumors. The fellow will apply high-throughput screening, T-cell engineering, and single-cell analytics to identify and validate novel receptor designs that enhance anti-tumor activity. This role offers the opportunity to drive impactful preclinical research in a collaborative, multidisciplinary environment. Ideal candidates will have experience in cellular immunotherapy, molecular cloning, and data analysis, with a strong interest in developing innovative cancer treatments.

  Job Duties

  • Designs and executes experiments involving CAR T-cell engineering, transduction, and functional assays, as well as barcoded DNA libraries.
  • Analyzes pooled barcoded screens and single-cell RNA-seq datasets using bioinformatics tools.
  • Maintains detailed electronic lab notebooks and prepare figures for presentations, manuscripts, and progress reports.
  • Supports grant proposals by contributing data, methods, and experimental insights for funded and future applications.
  • Mentors and trains research assistants, students, and rotating trainees in lab techniques and data analysis workflows.
  • Presents findings at weekly lab meetings and contribute to Center-wide seminars and collaborative discussions.

  Minimum Qualifications

  • MD or Ph.D. in Basic Science, Health Science, or a related field.
  • No experience required.

  Preferred Qualifications

  • Ph.D. in Immunology, Cancer Biology, Biomedical Engineering, Molecular/Cell Biology, or a closely related field.
  • Hands-on experience in T-cell engineering, including lentiviral/retroviral vector design, transduction, and functional immune assays.
  • Proficiency in multi-parameter flow cytometry, including panel design, compensation, and data interpretation.
  • Experience with single-cell and bulk RNA-seq workflows, including sample preparation and downstream analysis.
  • Familiarity with barcoded pooled screening techniques or other high-throughput genetic screens.
  • Prior experience with mouse models (e.g., xenograft or humanized models), including tumor monitoring and tissue processing.
  • Strong organizational skills, attention to detail, and commitment to rigorous data documentation and reproducibility.
  • Excellent communication and interpersonal skills, with a demonstrated ability to work both independently and as part of a collaborative team.
  • Experience mentoring junior trainees or contributing to a team-based research environment is a plus.

  Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

  PD; SN

• Apply

•  Contact information:
• Baylor College of Medicine